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About

Shigehiro Yoshida is a leading figure in functional genomics, best known for his pivotal contributions to the FANTOM5 project, where he helped map transcription initiation events across the human and mouse genomes at single base-pair resolution. His work using Cap Analysis of Gene Expression (CAGE) coupled with single-molecule sequencing has provided an unprecedented view of promoter and enhancer usage across nearly three thousand samples, fundamentally advancing our understanding of gene regulation. This landmark study, published in 2017, has garnered over 360 citations, reflecting its profound impact on the field. Yoshida’s research lies at the intersection of transcriptomics, computational biology, and regulatory genomics, with a focus on decoding the complex architecture of mammalian genomes. His contributions have not only enabled the systematic annotation of transcription start sites but have also empowered researchers worldwide to explore cell-type-specific gene expression patterns. Through his meticulous work, Yoshida has helped establish a foundational resource that continues to drive discoveries in development, disease, and evolution.