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Eri Saijyo is a leading figure in functional genomics, best known for transformative contributions to the FANTOM5 project, which systematically mapped transcription initiation events across the human and mouse genomes. Her landmark 2017 paper, cited over 360 times, established comprehensive CAGE (Cap Analysis of Gene Expression) profiles at single base-pair resolution, enabling precise quantification of promoter and enhancer activity across thousands of samples. This work fundamentally advanced our understanding of transcriptional regulation and provided an invaluable resource for the genomics community. Saijyo’s expertise in high-throughput sequencing and bioinformatics has been instrumental in decoding complex gene regulatory networks, with her datasets serving as foundational references for studies in development, disease, and evolution. Her achievements include pioneering the use of single-molecule sequencing for large-scale transcriptome analysis, which has set new standards for reproducibility and depth in expression profiling. Through her rigorous, collaborative efforts, Saijyo has empowered researchers worldwide to explore the dynamic landscape of transcription initiation, making her a key architect of modern functional genomics.