Scott Classen
Papers
1
Total Citations
259
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About
Scott Classen is a leading structural biologist whose work bridges the gap between static protein structures and dynamic biological function. He is best known for his pioneering contributions to small-angle X-ray scattering (SAXS) and macromolecular crystallography (MX), particularly through his instrumental role in developing the SIBYLS beamline (12.3.1) at the Advanced Light Source. His landmark 2013 paper on SIBYLS, cited over 250 times, describes how this dual endstation uniquely enables researchers to study proteins in solution and in crystallo, providing complementary views of molecular shape and flexibility. Classen’s research has significantly advanced our understanding of protein conformational changes, DNA repair mechanisms, and immune system signaling. His work has been widely recognized for its impact on the structural biology community, enabling thousands of experiments that connect atomic-resolution structures to functional dynamics. By making SAXS accessible and reliable for the broader community, Classen has helped democratize a powerful technique, cementing his legacy as a key architect of modern integrative structural biology.
Research Focus
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