James M. Holton
Papers
2
Total Citations
266
H-Index
2
About
James M. Holton is a leading figure in structural biology, renowned for his pioneering work at the intersection of macromolecular crystallography (MX) and small-angle X-ray scattering (SAXS). His most impactful contribution is the design and implementation of the SIBYLS beamline (12.3.1) at the Advanced Light Source, a unique dual-endstation facility that seamlessly integrates both SAXS and MX capabilities. This groundbreaking instrument, supported by the DOE and NIH, has garnered over 259 citations, enabling researchers to probe biological structures across multiple scales—from atomic detail to solution-state conformations—within a single experiment. Holton’s expertise extends to advancing automated crystallography pipelines, as demonstrated in his work on the ELVES system, which optimizes data processing for high-throughput structural genomics. His efforts have significantly streamlined the path from crystallization to structure determination, accelerating discoveries in fields ranging from drug design to molecular biophysics. With a career marked by technical innovation and a deep commitment to open-access beamline science, Holton remains an indispensable resource for the structural biology community, empowering researchers worldwide to tackle complex biological questions with unprecedented efficiency.
Research Focus
Key Achievements
Top Papers
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