John A. Tainer
Papers
2
Total Citations
402
H-Index
2
About
John A. Tainer is a pioneering structural biologist whose research bridges the gap between molecular form and biological function, with a particular focus on DNA repair, cancer biology, and cellular responses to stress. His major contributions include the development and implementation of cutting-edge technologies for structural biology, most notably the SIBYLS beamline at the Advanced Light Source, which uniquely combines small-angle X-ray scattering (SAXS) and macromolecular crystallography (MX). This dual-endstation facility, described in a highly cited 2013 paper (259 citations), has become an essential resource for the structural biology community, enabling researchers to study dynamic macromolecular complexes in solution. Tainer also led the development of MacroBac, a robust system for large-scale production of recombinant multiprotein complexes (143 citations, 2017), addressing a critical bottleneck in structural biology. His work has fundamentally advanced our understanding of how proteins and their complexes orchestrate DNA repair pathways, with implications for cancer therapeutics and aging. A member of the National Academy of Sciences, Tainer’s research continues to shape the field through innovative methods and mechanistic insights.
Research Focus
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Top Papers
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