Patrick J. McGuire
Papers
1
Total Citations
259
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1
About
Patrick J. McGuire is a leading figure in structural biology and X-ray scattering instrumentation. His primary research focuses on the development and application of advanced synchrotron beamlines, particularly for small-angle X-ray scattering (SAXS) and macromolecular crystallography (MX). McGuire’s most significant contribution is his central role in the design, implementation, and optimization of the SIBYLS beamline (12.3.1) at the Advanced Light Source. This dual endstation facility, uniquely optimized for both SAXS and MX, has become a critical resource for the structural biology community, enabling researchers to study the solution structures of biomolecules with unprecedented efficiency. The seminal paper detailing SIBYLS’s performance has garnered over 259 citations, underscoring its profound impact. His work has empowered countless studies on protein folding, interactions, and dynamics, bridging the gap between high-resolution crystallography and solution-state analysis. Supported by the DOE and NIH, McGuire’s engineering and scientific vision has provided a transformative tool that continues to drive discovery in molecular biophysics.
Research Focus
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Top Papers
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