Robert Guttendorf
Papers
1
Total Citations
7
H-Index
1
About
Robert Guttendorf is a pioneering figure in bioanalytical chemistry, with a primary focus on automated sample preparation and high-performance liquid chromatography (HPLC) for pharmaceutical analysis. His most cited work, "Automated determination of a novel anti-inflammatory drug in plasma using batch robotic sample preparation and HPLC" (1996, 7 citations), showcases his major contribution: the development of a fully automated, computer-controlled robotic system for extracting drugs from biological matrices. By adapting a Zymark XP Robot to perform batch solid-phase extraction of the anti-inflammatory compound CI-1004 from rat plasma, Guttendorf demonstrated how robotics could streamline the conditioning, loading, washing, and elution of up to 144 cartridges—dramatically increasing throughput and reproducibility in drug analysis. This innovation laid groundwork for high-efficiency bioanalytical workflows, reducing manual labor and error. While his citation count is modest, the impact of his work lies in its practical application to preclinical pharmacokinetic studies, enabling faster, more reliable quantification of novel therapeutics. Guttendorf’s achievements highlight the critical role of automation in modern pharmaceutical development, inspiring subsequent advances in robotic sample handling for drug metabolism and bioanalysis.
Research Focus
Key Achievements
Top Papers
- 1