Papers
3
Total Citations
132
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3
About
Thomas L. Lloyd is a pioneer in high-throughput bioanalytical chemistry, specializing in the automation of sample preparation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pharmaceutical analysis. His most influential work, a 2002 paper with 92 citations, introduced a groundbreaking high-speed gradient parallel LC-MS/MS system coupled with fully automated sample preparation, enabling the extraction and analysis of 1,152 plasma samples in just 10 hours—a remarkable 30 seconds per sample. This innovation dramatically accelerated bioanalysis for drug development, setting new standards for efficiency and throughput. Lloyd’s earlier foundational contributions include a 1992 validated robotic solid-phase extraction and HPLC assay for ranitidine in serum or plasma (27 citations) and a 1996 method for alosetron determination using robotic sample preparation (13 citations). These works demonstrated the ruggedness and reliability of automated systems in clinical bioanalysis, paving the way for modern high-throughput workflows. Lloyd’s legacy lies in transforming labor-intensive manual processes into rapid, reproducible, and scalable automated solutions, profoundly impacting the speed and accuracy of pharmacokinetic studies and therapeutic drug monitoring.
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