Keith L. Hoffman
Papers
3
Total Citations
133
H-Index
3
About
Keith L. Hoffman is a pioneering analytical chemist whose career has been defined by advancing automated and high-throughput sample preparation techniques for quantifying drugs in biological matrices. Working at the intersection of pharmaceutical analysis and bioanalytical chemistry, Hoffman has made significant contributions to streamlining drug quantification workflows that are essential in both preclinical and clinical research settings. His most influential work, a 2000 study on semi-automated 96-well liquid–liquid extraction for drug quantitation in biological fluids, garnered 76 citations and helped establish efficient, scalable approaches to bioanalytical sample processing. This was complemented by his earlier 1996 research adapting Zymark robotic systems for solid-phase extraction of anti-inflammatory compounds from rat plasma, demonstrating his early embrace of laboratory automation. His 2013 comparative study examining acetaminophen quantification across plasma, cerebrospinal fluid, and dried blood spots using LC-MS/MS — earning 50 citations — showcased his versatility across diverse biological sample types and cutting-edge detection technologies. Hoffman's body of work has meaningfully shaped how pharmaceutical scientists approach drug measurement, offering practical, reproducible solutions that continue to inform bioanalytical method development across the research community.
Research Focus
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Top Papers
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