James Stevens

Torrey Pines Institute For Molecular Studies

Papers

Total Citations

1,099

H-Index

About

James Stevens is a leading figure in glycobiology, whose work has fundamentally advanced our understanding of how glycans mediate biological recognition. His primary research focuses on the development and application of high-throughput tools to probe glycan-protein interactions, with a particular emphasis on viral pathogenesis and immune response. Stevens’s most transformative contribution is the creation of the printed covalent glycan array, a technology detailed in his landmark 2004 paper, which has garnered over 1,100 citations. By using standard robotic printing to couple amine-functionalized glycans to glass slides, he enabled the rapid, parallel profiling of hundreds of glycan structures against diverse binding proteins. This innovation revolutionized the field, providing a powerful platform for mapping the specificity of influenza hemagglutinins, antibodies, and lectins. The array has become an indispensable resource for studying host-pathogen interactions and vaccine design. Stevens’s work has had a profound impact on both basic science and public health, cementing his reputation as a pioneer in functional glycomics and a key architect of modern glycan analysis.