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About

Chi-Huey Wong is a pioneering figure in chemical biology and glycobiology, renowned for his transformative contributions to the study of carbohydrates and their biological functions. His research centers on the development of innovative tools to probe glycan-mediated interactions, with a particular focus on glycan arrays and enzymatic synthesis. Among his most impactful works is the creation of a printed covalent glycan array, which enabled high-throughput profiling of glycan-binding proteins using 200 synthetic and natural sequences. This landmark 2004 paper has garnered over 1,099 citations, establishing a foundational platform for deciphering the “glycocode” in health and disease. Wong further advanced the field with a novel glycan array on aluminum oxide-coated glass slides, employing phosphonate chemistry to facilitate both covalent and noncovalent immobilization. This 2010 study, with 62 citations, expanded the toolkit for studying enzymatic reactions and protein binding with enhanced versatility. A member of the U.S. National Academy of Sciences and a recipient of numerous international awards, Wong’s work has profoundly shaped our understanding of carbohydrate recognition, with broad implications for drug discovery, vaccine development, and diagnostics. His legacy continues to inspire researchers exploring the complex world of glycans.