Irma van Die
Papers
1
Total Citations
1,099
H-Index
1
About
Irma van Die is a leading figure in glycobiology, renowned for her pioneering work on glycan-mediated interactions in immunity and infectious disease. Her research centers on how complex carbohydrate structures—particularly those from parasitic helminths—modulate host immune responses. Van Die’s most impactful contribution is the development of the printed covalent glycan array, described in her landmark 2004 paper (over 1,100 citations). This technology, which uses robotic printing to immobilize hundreds of synthetic and natural glycans on glass slides, revolutionized the high-throughput profiling of glycan-binding proteins, enabling rapid discovery of lectin and antibody specificities. Her work has been instrumental in identifying immunomodulatory glycans from schistosomes and other parasites, revealing mechanisms of Th2 immune polarization and allergy protection. With a career spanning decades at Vrije Universiteit Amsterdam, van Die’s arrays have become essential tools worldwide, advancing vaccine design and diagnostics. Her research bridges basic glycobiology and translational immunology, making her a pivotal figure in understanding how sugars shape host-pathogen dialogues.
Research Focus
Key Achievements
Top Papers
- 1Printed covalent glycan array for ligand profiling of diverse glycan binding proteins1,099 citations · 2004