Margaret E. Huflejt
Papers
1
Total Citations
1,099
H-Index
1
About
Dr. Margaret E. Huflejt is a pioneering figure in glycobiology, whose work has fundamentally advanced our understanding of how glycan-binding proteins decode the "sugar code" that governs cellular communication. Her key research areas include the development of high-throughput glycan microarray technology and the functional characterization of lectins, particularly galectins. Dr. Huflejt’s most transformative contribution is her seminal 2004 paper on the "Printed covalent glycan array for ligand profiling of diverse glycan binding proteins," which has garnered over 1,100 citations. This work introduced a robust, reproducible method for immobilizing synthetic and natural glycans on glass slides, enabling the rapid, parallel screening of hundreds of glycan structures against proteins, viruses, and antibodies. By creating this platform, she provided the field with an indispensable tool for mapping glycan-protein interactions, directly impacting vaccine development, cancer biomarker discovery, and the study of infectious diseases. Her achievements have established a gold standard for glycan profiling, making her a foundational contributor to modern functional glycomics and an inspiration for researchers exploring the complex language of carbohydrates.
Research Focus
Key Achievements
Top Papers
- 1Printed covalent glycan array for ligand profiling of diverse glycan binding proteins1,099 citations · 2004