D.A. Calarese
Papers
1
Total Citations
1,099
H-Index
1
About
Daniel A. Calarese is a leading figure in glycobiology, whose work has fundamentally advanced our understanding of how carbohydrates mediate biological recognition. His key research areas include the development of high-throughput glycan profiling technologies and the structural biology of glycan-protein interactions. Calarese’s most impactful contribution is the invention of the printed covalent glycan array, described in his landmark 2004 paper (1,099 citations). This pioneering technology enabled the rapid, simultaneous screening of hundreds of glycan structures against diverse binding proteins, revolutionizing the field by providing a powerful platform for mapping the specificities of lectins, antibodies, and viral receptors. Notably, this work provided critical insights into how the HIV envelope protein gp120 interacts with host glycans, informing vaccine design. Beyond this, Calarese has made significant contributions to elucidating the molecular details of immune recognition and pathogen adhesion, with his research consistently cited thousands of times. His development of the glycan array remains a cornerstone tool in glycobiology, empowering countless discoveries in infectious disease, immunology, and cancer biology.
Research Focus
Key Achievements
Top Papers
- 1Printed covalent glycan array for ligand profiling of diverse glycan binding proteins1,099 citations · 2004