Papers
3
Total Citations
85
H-Index
2
About
Gilles Labesse is a structural biologist whose research lies at the intersection of X-ray crystallography, protein engineering, and fragment-based drug design. His most impactful contribution is the development of an innovative in-plate protein crystallization method, coupled with in situ ligand soaking and X-ray diffraction, detailed in a 2011 paper that has garnered 78 citations. This technique streamlines the traditionally laborious process of protein crystal handling, enabling high-throughput screening of small-molecule ligands directly within crystallization plates. By automating the structural determination of protein-ligand complexes, Labesse’s work has significantly advanced fragment-based drug design, offering a more efficient pathway for identifying lead compounds. His broader research, reflected in works like "From Molecular Modeling to Drug Design" and "Fragment and Conquer," underscores a commitment to bridging computational modeling and experimental structural biology. Labesse’s contributions have not only enhanced the automation and throughput of crystallographic methods but also provided a practical toolkit for researchers aiming to accelerate drug discovery, making him a notable figure in the field of structural biology and medicinal chemistry.
Research Focus
Key Achievements
Top Papers
- 1
- 2From Molecular Modeling to Drug Design5 citations · 2007
- 3Fragment and Conquer: From Structure to Complexes to Function2 citations · 2012