Albane le Maire
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1
Total Citations
78
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1
About
Albane le Maire is a structural biologist whose work has significantly advanced the field of X-ray crystallography, particularly for fragment-based drug design. Her most-cited research, "In-plate protein crystallization, in situ ligand soaking and X-ray diffraction" (2011, 78 citations), tackles a critical bottleneck in structural biology: the tedious manual handling of protein crystals. By developing an innovative method for in-plate crystallization and in situ ligand soaking, she enabled direct X-ray diffraction from crystallization plates, eliminating the need for crystal harvesting and cryoprotection. This streamlined approach has been widely adopted for high-throughput ligand screening, allowing researchers to rapidly determine protein–small molecule complex structures. Le Maire’s contributions have helped automate and accelerate drug discovery pipelines, making her a key figure in the integration of crystallography with fragment-based approaches. Her work continues to influence how structural biologists design experiments for efficient, high-resolution studies of protein–ligand interactions.
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