Muriel Gelin
Papers
1
Total Citations
78
H-Index
1
About
Muriel Gelin is a structural biologist whose work has significantly advanced the field of fragment-based drug design through innovative X-ray crystallography techniques. Her research focuses on developing streamlined methods for protein-ligand complex structure determination, particularly through in-plate protein crystallization and in situ ligand soaking. Gelin’s most cited work, a 2011 paper with 78 citations, introduced a groundbreaking approach that eliminates the tedious crystal handling steps traditionally required for ligand screening. By enabling direct soaking of small molecules into crystals grown in specialized plates, followed by in situ X-ray diffraction, her method dramatically accelerates the identification of protein-ligand interactions. This contribution has been instrumental in automating fragment screening pipelines, making structural biology more accessible for early-stage drug discovery. Gelin’s work bridges the gap between crystallization and high-throughput screening, allowing researchers to rapidly obtain high-resolution structures of protein-fragment complexes without manual crystal manipulation. Her innovative protocols have become a cornerstone for laboratories seeking efficient, automated approaches to structural studies, demonstrating how method development can transform the pace of drug design and molecular understanding.
Research Focus
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Top Papers
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