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Shigeyuki Yokoyama is a structural biologist and proteomics pioneer whose research has profoundly shaped our understanding of protein structure, function, and large-scale genomic analysis. His work sits at the intersection of structural genomics, cell-free protein expression, and computational drug discovery, making him a central figure in postgenomic-era biology. Yokoyama's most influential contribution, "Protein Expression Systems for Structural Genomics and Proteomics" (2003, 256 citations), established foundational methodologies for producing proteins at scale — a critical bottleneck in structural biology. Building on this, he developed automated high-throughput platforms, including a cell-free dialysis system for protein production (2009, 64 citations), significantly accelerating the pace of structural determination. His interdisciplinary reach extends into rational drug discovery, where he pioneered a strategy combining in silico screening with surface plasmon resonance to identify small-molecule ligands for functionally uncharacterized proteins (2005, 64 citations). His whole-cell structural genomics project on the thermophilic bacterium *Thermus thermophilus* HB8 further demonstrated his commitment to systematic, organism-wide protein characterization, encompassing crystallization screening and novel membrane protein crystallization instrumentation. Collectively, Yokoyama's work has provided the structural biology community with transformative tools, bridging genomics, biophysics, and drug development.