Ayako Tatsuguchi
Papers
1
Total Citations
2
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About
Ayako Tatsuguchi has made her mark in structural biology, with a primary focus on elucidating the three-dimensional architecture of proteins from extremophilic organisms. Her most cited work centers on the X-ray crystallographic analysis of TT1751, a conserved hypothetical protein from the thermophilic bacterium *Thermus thermophilus* HB8. This research, published in 2004, leveraged the exceptional stability of proteins from this heat-loving microbe, which are ideally suited for structural studies at room temperature. By solving the crystal structure of TT1751, Tatsuguchi contributed to the broader effort of functionally annotating the genome of *T. thermophilus*, a model organism for understanding thermostability and protein evolution. While her work has garnered modest citation counts, its significance lies in its foundational role within structural genomics initiatives, providing key insights into the molecular adaptations that enable life at extreme temperatures. Her contributions highlight the importance of combining crystallography with extremophile biology to unlock the functions of previously uncharacterized proteins.
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