Papers
4
Total Citations
327
H-Index
3
About
Linda S. Brinen is a structural biologist whose research has made significant contributions to drug discovery, structural genomics, and enzymology. She is perhaps best known for her landmark 2009 study on vinyl sulfones as antiparasitic agents, which garnered 296 citations and provided critical crystal structures of cysteine proteases from the papain superfamily — enzymes central to the virulence of parasitic diseases. By elucidating the structural basis for drug-enzyme interactions, her work directly advanced the rational design of antiparasitic therapeutics targeting these promising molecular candidates. Brinen has also contributed meaningfully to structural genomics through high-resolution crystallographic studies of proteins from *Thermotoga maritima*, including γ-glutamyl phosphate reductase and uronate isomerase, shedding light on key metabolic enzymes involved in proline biosynthesis and sugar metabolism. Her earlier work on systematic protein crystal characterization further reflects a commitment to building the infrastructure needed for large-scale structural biology. Collectively, her research bridges fundamental biochemistry with translational applications, offering both mechanistic insights and practical frameworks for combating infectious and parasitic diseases — making her work an enduring reference point for researchers in chemical biology and drug development.
Research Focus
Key Achievements
Top Papers
- 1Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design296 citations · 2009
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