Papers
2
Total Citations
28
H-Index
2
About
Xianhong Wang is a structural biologist whose work has illuminated the molecular machinery of thermophilic bacteria, with a particular focus on the hyperthermophile *Thermotoga maritima*. Wang’s major contributions lie in solving the three-dimensional structures of key metabolic enzymes, providing atomic-level insights into their function and stability. Notably, Wang determined the crystal structure of γ-glutamyl phosphate reductase (GPR), an enzyme essential for proline biosynthesis, revealing the architecture of its NADPH-dependent catalytic mechanism. This work, cited 18 times, has been foundational for understanding amino acid metabolism in extreme environments. Additionally, Wang elucidated the structure of uronate isomerase, an enzyme critical for the breakdown of sugar acids like D-glucuronate and D-galacturonate, a pathway important for carbon utilization. With 10 citations, this study advanced knowledge of carbohydrate metabolism in thermophiles. Wang’s research, conducted at the forefront of structural genomics, has provided a valuable resource for the scientific community, offering detailed models that underpin further investigations into enzyme evolution, thermostability, and biotechnological applications.
Research Focus
Key Achievements
Top Papers
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