Papers
2
Total Citations
28
H-Index
2
About
John Wooley is a structural biologist whose work has illuminated the functional machinery of extremophilic bacteria, with a particular focus on the hyperthermophile *Thermotoga maritima*. His research centers on determining the three-dimensional structures of key metabolic enzymes, providing atomic-level insights into proline biosynthesis and sugar metabolism. Wooley’s landmark contributions include solving the crystal structure of γ-glutamyl phosphate reductase (GPR), the enzyme catalyzing the second step of proline production, and uronate isomerase, which is critical for the breakdown of uronic acids. These structures, determined at resolutions of 2.0 Å and 2.85 Å respectively, have been cited over 28 times collectively, serving as foundational references for understanding enzyme evolution and thermostability. By elucidating the molecular architecture of these proteins, Wooley has advanced our knowledge of how life adapts to extreme environments and has provided structural templates for biotechnological applications. His work stands as a testament to the power of structural genomics in unraveling the complex biochemistry of thermophilic organisms.
Research Focus
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