Kevin Rodrigues
Scripps Research Institute, Joint Center for Structural Genomics
Papers
2
Total Citations
28
H-Index
2
About
Kevin Rodrigues has made significant contributions to structural biology, with a focus on elucidating the three-dimensional structures of key enzymes from the hyperthermophilic bacterium *Thermotoga maritima*. His work centers on understanding the molecular mechanisms of metabolic pathways, particularly proline biosynthesis and sugar metabolism. Rodrigues solved the crystal structure of γ-glutamyl phosphate reductase (GPR), the enzyme catalyzing the second step of proline synthesis, revealing the NADPH-dependent reduction mechanism at 2.0 Å resolution. He also determined the structure of uronate isomerase, an enzyme involved in the conversion of uronic acids like D-glucuronate, providing insight into carbohydrate catabolism at 2.85 Å resolution. Though his most-cited papers have accumulated modest citation counts (18 and 10, respectively), they represent foundational structural characterizations of thermostable enzymes, offering valuable templates for understanding protein stability and function at high temperatures. His work has implications for biotechnology, including the engineering of robust biocatalysts for industrial applications. Rodrigues’ structural studies continue to inform research on extremophile biology and enzyme evolution.
Research Focus
Key Achievements
Top Papers
- 1
- 2