Henry van den Bedem
SLAC National Accelerator Laboratory, Stanford University, Biotechnology Research Institute
Papers
5
Total Citations
65
H-Index
4
About
Henry van den Bedem is a computational structural biologist whose research bridges experimental crystallography and computational modeling to advance our understanding of protein structure, dynamics, and function. Working prominently within the Joint Center for Structural Genomics (JCSG), he contributed to large-scale, automated structure-determination pipelines such as Xsolve, helping revolutionize high-throughput structural genomics under the NIH Protein Structure Initiative. His early crystallographic work yielded atomic-resolution structures of enzymes from the thermophilic organism *Thermotoga maritima*, including γ-glutamyl phosphate reductase and uronate isomerase, illuminating key metabolic pathways and earning sustained citation in the structural biology community. Beyond static structures, van den Bedem has pushed the frontier of protein dynamics, developing frustration-guided motion planning algorithms to computationally model conformational transitions — work that addresses the fundamental challenge of understanding how proteins move between functional states. His contributions span structural genomics infrastructure, enzyme biochemistry, and protein conformational modeling, collectively cited dozens of times across disciplines. His career exemplifies the productive integration of robotics-inspired computation with experimental biology, offering students a model for interdisciplinary approaches to understanding molecular machines.
Research Focus
Key Achievements
Top Papers
- 1Distributed structure determination at the JCSG26 citations · 2011
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