Papers
1
Total Citations
80
H-Index
1
About
Sacha Grisel is a structural biologist whose work has advanced the field of high-throughput protein crystallography. His key research focuses on developing and optimizing crystallization methodologies to determine protein structures at scale. Grisel’s major contribution is demonstrating the effectiveness of a medium-throughput crystallization approach, which combines robotic large-scale screening with manual or automated optimization of conditions. This two-step strategy, detailed in his highly cited 2002 paper (80 citations), provided early, clear evidence that such hybrid pipelines could accelerate structural genomics programs. By bridging the gap between fully automated and traditional manual methods, Grisel’s work helped establish practical workflows that maximize success rates while managing resource demands. His findings have been instrumental for researchers seeking to solve protein structures efficiently, making his approach a foundational reference in the structural biology community.
Research Focus
Key Achievements
Top Papers
- 1A medium-throughput crystallization approach80 citations · 2002