M. Gary Newton

About

M. Gary Newton is a structural biologist whose research has focused on advancing the efficiency and scalability of protein crystallography and structural genomics. Working within the Southeast Collaboratory for Structural Genomics (SECSG), Newton made significant contributions to the development of high-throughput protein-to-structure pipelines, integrating robotics and automation to dramatically accelerate the process of determining protein structures through X-ray diffraction. His 2005 work on this pipeline, which has garnered 24 citations, demonstrated how systematic automation could transform what was once a labor-intensive process into a streamlined, reproducible workflow capable of handling large-scale structural genomics projects. Complementing this, Newton also contributed innovative methodological improvements to protein crystallization itself, including a novel screening and optimization strategy that reduced the number of trials needed to produce diffraction-quality crystals, alongside a practical modification to the Douglas Instruments ORYX robot that effectively doubled its screening capacity. This work, cited 20 times, reflects Newton's pragmatic approach to solving bottlenecks in structural biology workflows. Together, his contributions have helped lay important groundwork for the broader field of structural genomics, making high-resolution protein structure determination faster and more accessible to the research community.

Research Focus

Key Achievements

Top Papers

1. 1
   The high-throughput protein-to-structure pipeline at SECSG

   24 citations · 2005
2. 2
   On increasing protein-crystallization throughput for X-ray diffraction studies

   20 citations · 2005

Key Collaborators

Contact & Links