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About

Dr. Jessie Chang is a pioneering structural biologist whose work has significantly advanced high-throughput protein crystallography. Her primary research focuses on developing automated pipelines for protein structure determination, with a major contribution being the design and integration of the high-throughput protein-to-structure pipeline at the Southeast Collaboratory for Structural Genomics (SECSG). This groundbreaking system, detailed in her highly cited 2005 paper (24 citations), streamlined the entire process from protein screening to structure solution by incorporating robotics and automation. By reducing manual intervention and increasing throughput, Dr. Chang’s work enabled the rapid characterization of protein structures at an unprecedented scale, accelerating discoveries in structural genomics and drug design. Her achievements have set a benchmark for automation in the field, making her a key figure in the transition from traditional, labor-intensive crystallography to modern, high-efficiency methods. Dr. Chang’s contributions continue to inspire researchers seeking to leverage automation for large-scale biological insights.