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About

Doowon Lee is a structural biologist whose work has advanced the high-throughput determination of protein structures, a cornerstone of modern drug discovery and functional genomics. As a key contributor to the Southeast Collaboratory for Structural Genomics (SECSG), Lee helped design and implement an automated protein-to-structure pipeline that integrates robotics and streamlined protocols for crystallization, data collection, and structure solution. His most-cited paper, “The high-throughput protein-to-structure pipeline at SECSG” (2005, 24 citations), details this system’s capacity to screen thousands of targets efficiently, significantly reducing the time from gene to three-dimensional model. This work laid the foundation for large-scale structural genomics initiatives, enabling rapid characterization of proteins from diverse organisms. Lee’s contributions have been instrumental in demonstrating how automation can overcome bottlenecks in crystallography, making structural data more accessible to the broader research community. His efforts continue to influence the design of high-throughput pipelines in structural biology labs worldwide.