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About

Shu-Huey Chang is a structural biologist whose work has been instrumental in advancing high-throughput protein crystallography. Her research focuses on developing automated pipelines for protein structure determination, with a major contribution being the design and implementation of the high-throughput protein-to-structure pipeline at the Southeast Collaboratory for Structural Genomics (SECSG). This system integrates robotics and automation to streamline the entire process—from protein expression to X-ray structure solution—significantly accelerating the pace of structural genomics. Her seminal 2005 paper detailing this pipeline has garnered 24 citations, reflecting its foundational role in the field. Chang’s achievements include enabling the rapid screening and structure determination of thousands of proteins, which has broad implications for drug discovery and understanding biological function. Her work stands as a model for integrating automation into structural biology, making her a key figure in the push toward high-efficiency, large-scale protein characterization.