Papers
1
Total Citations
80
H-Index
1
About
L. Miallau is a structural biologist whose work has significantly advanced the field of protein crystallography, particularly through the development and implementation of medium-throughput crystallization strategies. Their most notable contribution, the 2002 paper "A medium-throughput crystallization approach" (80 citations), established a pioneering two-step pipeline that combines large-scale robotic screening with manual or automated optimization of crystallization conditions. This work provided the first concrete results from a medium-scale structural genomics program, demonstrating how automation could dramatically accelerate the process of obtaining protein crystals for X-ray diffraction studies. By bridging the gap between low-throughput manual methods and high-throughput industrial approaches, Miallau's methodology became a foundational framework for structural genomics initiatives worldwide. Their research has been instrumental in making protein structure determination more efficient and accessible, directly impacting how laboratories approach crystallization—a critical bottleneck in structural biology. Through this work, Miallau has helped shape modern structural genomics, enabling researchers to tackle increasingly complex biological systems and contributing to the broader understanding of protein function and drug design.
Research Focus
Key Achievements
Top Papers
- 1A medium-throughput crystallization approach80 citations · 2002