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Alain Grossi is a structural biologist whose pioneering work in medium-throughput crystallization has significantly advanced the field of structural genomics. His most influential contribution, the 2002 paper "A medium-throughput crystallization approach" (80 citations), established a transformative two-step methodology that combines large-scale robotic screening with manual or automated optimization of crystallization conditions. This innovative approach demonstrated the practical value of integrating automation with traditional techniques, enabling researchers to more efficiently determine protein structures on a medium scale. Grossi's work laid crucial groundwork for modern structural biology pipelines, bridging the gap between high-throughput automation and the nuanced optimization required for successful crystallization. His methodology has been widely adopted by structural genomics programs worldwide, accelerating the discovery of novel protein structures and facilitating drug design efforts. By showing that a balanced, medium-scale approach could yield robust results without the prohibitive costs of full automation, Grossi helped democratize access to structural determination techniques. His contributions continue to influence how laboratories approach protein crystallization, making him a key figure in the evolution of structural biology from a labor-intensive craft to a more systematic, reproducible science.