Peter M. Frederik
Papers
2
Total Citations
32
H-Index
2
About
Peter M. Frederik is a pioneer in the application of cryo-electron microscopy (cryo-EM) to biological systems, with a career dedicated to advancing the structural and ultrastructural analysis of cells and macromolecules. His key research areas include the development of cryo-EM methodologies for imaging intact cellular structures, particularly liver sinusoidal endothelial cells (LSECs), and the automation of sample preparation for high-resolution 2D and 3D imaging. Frederik’s major contributions include demonstrating that cryo-EM can preserve and visualize the delicate architecture of hepatic endothelial cells without the artifacts introduced by chemical fixation and drying, as shown in his 2003 study (19 citations). He further revolutionized the field by engineering an automated, robotic system for vitrifying samples, detailed in his 2005 work (13 citations), which dramatically improved reproducibility and throughput for cryo-EM studies. This innovation enabled researchers to capture dynamic biological processes at near-native states. Frederik’s work has had a lasting impact on structural biology, facilitating breakthroughs in understanding cellular barriers and macromolecular interactions. His achievements underscore a legacy of merging engineering with biology to push the limits of electron microscopy.
Research Focus
Key Achievements
Top Papers
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