Paul F. Laeseke
Papers
9
Total Citations
178
H-Index
6
About
Paul F. Laeseke is a pioneering biomedical engineer and interventional radiologist whose research is transforming the landscape of noninvasive cancer therapy. His work centers on three key areas: robotic needle steering for percutaneous interventions, image-guided histotripsy, and bronchoscopic ablation. Laeseke’s major contributions include developing highly articulated robotic needles capable of achieving distributed ablation of liver tissue without multiple punctures, as demonstrated in his 2017 work (36 citations). He has also been instrumental in advancing histotripsy—a noninvasive, nonthermal focused ultrasound therapy—by creating targeting systems that integrate mobile C-arm cone beam CT guidance, overcoming the limitations of conventional ultrasound for deep or isoechoic tumors. His 2022 paper on an X-ray C-arm guided automatic targeting system (26 citations) and subsequent in vivo porcine model studies (21 citations) have established a framework for precise, nonionizing tumor ablation. With over 178 total citations across his most-cited works, Laeseke’s research is driving the clinical translation of robotic and image-guided technologies, offering safer, more effective treatments for liver and lung cancers. His notable achievements include device safety assessments for bronchoscopic microwave ablation using robotic-assisted bronchoscopy, further expanding the arsenal of minimally invasive cancer therapies.
Research Focus
Key Achievements
Top Papers
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- 3An X-Ray C-Arm Guided Automatic Targeting System for Histotripsy26 citations · 2022
- 4Transcostal Histotripsy Ablation in an In Vivo Acute Hepatic Porcine Model21 citations · 2021
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- 6A histotripsy targeting approach using a mobile C-arm7 citations · 2023
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