Michael A. Speidel
Papers
5
Total Citations
45
H-Index
4
About
Michael A. Speidel is a leading researcher in the development of image-guided histotripsy, a noninvasive, nonthermal, and nonionizing focal cancer therapy that uses focused ultrasound to mechanically destroy tumors. His work centers on overcoming the limitations of conventional ultrasound guidance by pioneering the use of C-arm cone beam CT (CBCT) for precise targeting. Speidel’s major contributions include the design and validation of an X-ray C-arm guided automatic targeting system for histotripsy, which enables accurate treatment of deep or isoechoic lesions that are poorly visualized by ultrasound. His research has demonstrated the feasibility and accuracy of this approach in both phantom and in vivo porcine models, with studies reporting targeting accuracy and reproducibility. With over 45 citations across his most-cited works, Speidel’s innovations are advancing histotripsy toward broader clinical adoption. Notably, his 2022 paper on the automatic targeting system has garnered 26 citations, reflecting its impact on the field. Speidel’s work also addresses practical challenges such as calibration correction and single-pose image-to-robot registration, making mobile C-arm CBCT-guided histotripsy more accessible and reliable for future cancer treatments.
Research Focus
Key Achievements
Top Papers
- 1An X-Ray C-Arm Guided Automatic Targeting System for Histotripsy26 citations · 2022
- 2A histotripsy targeting approach using a mobile C-arm7 citations · 2023
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