Timothy J. Ziemlewicz
University of Wisconsin–Madison, UW Health University Hospital
Papers
8
Total Citations
267
H-Index
6
About
Timothy J. Ziemlewicz is a pioneering researcher in the field of noninvasive cancer therapy, with his work centered on histotripsy—a revolutionary non-thermal, non-ionizing focused ultrasound technique that mechanically liquefies tissue through cavitation. His major contributions include the development and preclinical validation of Robotically Assisted Sonic Therapy (RAST), demonstrating its feasibility for creating clinically relevant hepatic and renal ablations in porcine models. Ziemlewicz’s research has significantly advanced the translation of histotripsy to clinical practice, as evidenced by his leadership in the landmark #HOPE4LIVER single-arm pivotal trial (30 citations), which evaluated 1-year outcomes for primary and metastatic liver tumors. His work has garnered over 260 citations, with his 2018 proof-of-concept study in a porcine liver model alone accumulating 90 citations. Notably, he has addressed critical challenges such as mitigating body wall damage through modified pulse sequences and enhancing targeting accuracy with cone-beam CT guidance. Ziemlewicz’s innovations in automatic targeting systems and calibration correction have paved the way for precise, image-guided histotripsy, positioning him as a key figure in the evolution of noninvasive tumor ablation.
Research Focus
Key Achievements
Top Papers
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- 5An X-Ray C-Arm Guided Automatic Targeting System for Histotripsy26 citations · 2022
- 6Transcostal Histotripsy Ablation in an In Vivo Acute Hepatic Porcine Model21 citations · 2021
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