Martin Caffrey
Papers
15
Total Citations
1,149
H-Index
12
About
Martin Caffrey is a pioneering structural biologist whose career has been defined by transformative contributions to membrane protein crystallography. Working at the intersection of biophysics, structural biology, and automation, Caffrey is best known for developing and championing the lipid cubic phase (or *in meso*) method — a breakthrough technique that enabled the crystallization of notoriously difficult membrane proteins for high-resolution structure determination. His 2003 paper on membrane protein crystallization has garnered over 334 citations, while his comprehensive 2014 review of the *in meso* method accumulated 254 citations, reflecting the field's widespread adoption of his approach. Caffrey's innovations extend beyond methodology into practical implementation. He developed high-throughput robotic systems that made lipidic mesophase crystallization accessible and reproducible at scale, earning 146 citations for his 2004 robotics paper. His work has directly enabled landmark structural studies, including breakthroughs with G-protein-coupled receptors — some of the most pharmacologically significant proteins in biology. Later contributions, such as *in meso in situ* serial X-ray crystallography at cryogenic temperatures, further streamlined crystal data collection. With nearly 800 cumulative citations across his key publications, Caffrey's legacy is one of elegant technical ingenuity that has fundamentally advanced our understanding of membrane protein architecture.
Research Focus
Key Achievements
Top Papers
- 1Membrane protein crystallization334 citations · 2003
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