Xiangyu Liu
Papers
1
Total Citations
98
H-Index
1
About
Xiangyu Liu is a structural biologist whose work has significantly advanced the methodology of serial X-ray crystallography, particularly for challenging protein targets. His key research areas include membrane protein structure determination and the development of innovative crystallographic techniques. Liu’s major contribution is the introduction of an *in meso in situ* serial crystallography method that enables data collection from soluble and membrane proteins at cryogenic temperatures directly within the lipid cubic or sponge phase. This approach eliminates the technically demanding and inefficient step of crystal harvesting, streamlining the entire structure determination pipeline. With 98 citations, this foundational 2015 paper has become a key reference for researchers working on difficult-to-crystallize proteins, demonstrating its lasting impact on the field. By simplifying the experimental workflow, Liu’s work has made high-resolution structural studies more accessible, paving the way for deeper insights into the molecular mechanisms of membrane proteins and facilitating future drug discovery efforts.
Research Focus
Key Achievements
Top Papers
- 1