Nathalie Meier

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About

Nathalie Meier is a structural biologist whose research focuses on advancing methods for membrane protein crystallography, particularly through the development of innovative sample-handling techniques. Her major contributions center on simplifying the notoriously difficult process of studying membrane proteins, which are critical drug targets but challenging to crystallize. Meier pioneered the *in meso in situ* fixed-target serial X-ray crystallography method, a breakthrough that allows researchers to collect data from hundreds of tiny, fragile microcrystals directly in their growth medium—eliminating the need for delicate crystal harvesting. Her most-cited work, "3D-printed holders for *in meso in situ* fixed-target serial X-ray crystallography" (2020), with 13 citations, demonstrates her hands-on engineering approach to solving practical bottlenecks in structural biology. This method dramatically eases handling of small, fragile membrane protein crystals and enables rapid data collection at synchrotron sources. Meier’s work bridges 3D printing technology with cutting-edge crystallography, making high-resolution structural studies more accessible. Her achievements represent a significant step toward streamlining the structural determination of membrane proteins, with potential implications for drug discovery and understanding fundamental biological processes.