Abhiram Dukkipati
Papers
1
Total Citations
105
H-Index
1
About
Abhiram Dukkipati is a structural biologist whose work has fundamentally advanced our understanding of membrane protein signaling, particularly through the lens of G protein-coupled receptors (GPCRs). His research centers on the biophysical and structural mechanisms of transmembrane signaling, with a major focus on developing and applying cutting-edge crystallographic techniques. Dukkipati’s most influential contribution is his landmark 2012 review, *Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases: Recent Advances and Successes*, which has garnered over 105 citations. This work not only chronicled the revolutionary determination of the β₂-adrenergic receptor’s structure in complex with an agonist and its cognate G protein but also provided a critical methodological roadmap for the field. By detailing the use of lipidic mesophases (in meso) crystallization, Dukkipati helped demystify how researchers can capture the dynamic, signaling-competent states of these elusive receptors. His synthesis of these advances has been instrumental in enabling subsequent studies that explore, at atomic resolution, how a receptor binds an agonist and transmits that signal across the cell membrane—a process central to human physiology and drug discovery.
Research Focus
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Top Papers
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