Manikandan Lakshmanan
Papers
1
Total Citations
64
H-Index
1
About
Dr. Manikandan Lakshmanan is a leading researcher in cancer biology and targeted therapeutics, with a primary focus on protein N-myristoylation and its role in B-cell malignancies. His most impactful work, the 2020 study "Targeting N-myristoylation for therapy of B-cell lymphomas" (64 citations), systematically demonstrated that N-myristoyltransferase (NMT) is a viable therapeutic target in lymphoma. Dr. Lakshmanan’s research has been instrumental in elucidating how the N-terminal lipid modification myristoylation governs membrane targeting and oncogenic signaling in cancer cells, where NMT expression is frequently elevated. By validating NMT inhibition as a strategy to disrupt these pathways, his contributions have opened new avenues for drug development in hematologic cancers. With a growing citation record, his work bridges fundamental cell biology and translational oncology, offering a compelling rationale for targeting lipid modifications in therapy. Dr. Lakshmanan’s research continues to shape the understanding of post-translational regulation in cancer, making him a key figure in the quest for novel, mechanism-based treatments.
Research Focus
Key Achievements
Top Papers
- 1Targeting N-myristoylation for therapy of B-cell lymphomas64 citations · 2020