Luc G. Berthiaume
Papers
1
Total Citations
64
H-Index
1
About
Dr. Luc G. Berthiaume is a leading cell biologist whose research centers on the critical role of protein lipidation—specifically N-myristoylation—in cancer cell signaling and survival. His seminal work, "Targeting N-myristoylation for therapy of B-cell lymphomas" (2020, 64 citations), systematically investigates N-myristoyltransferase (NMT) as a therapeutic vulnerability in hematologic malignancies. By demonstrating that B-cell lymphomas rely on elevated NMT activity for membrane targeting and oncogenic signaling, Dr. Berthiaume established a compelling rationale for developing NMT inhibitors as targeted cancer therapies. His contributions have illuminated how this post-translational modification drives tumor progression, opening new avenues for drug development. With a career focused on translating fundamental lipid biology into clinical strategies, Dr. Berthiaume’s work has garnered significant attention from both basic scientists and translational researchers. His findings not only deepen our understanding of cancer metabolism but also position N-myristoylation as a promising, druggable axis in oncology—making his research essential reading for anyone interested in the intersection of lipid biochemistry and cancer therapeutics.
Research Focus
Key Achievements
Top Papers
- 1Targeting N-myristoylation for therapy of B-cell lymphomas64 citations · 2020