Maneka A. Perinpanayagam

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About

Dr. Maneka A. Perinpanayagam is a leading researcher in chemical biology and cancer therapeutics, with a primary focus on protein myristoylation—a critical lipid modification that governs membrane targeting and cell signaling. Her most impactful work, the landmark 2020 study "Targeting N-myristoylation for therapy of B-cell lymphomas" (64 citations), systematically investigated N-myristoyltransferases (NMTs) as anti-cancer targets, demonstrating that cancer cells frequently upregulate NMT expression. This foundational research provided the first comprehensive evidence that pharmacological inhibition of N-myristoylation can selectively disrupt oncogenic signaling in B-cell malignancies, opening a new therapeutic avenue for lymphoma treatment. Dr. Perinpanayagam's contributions have been instrumental in advancing our understanding of how post-translational modifications drive cancer progression, and her work continues to influence the development of targeted therapies. Her research bridges fundamental biochemistry with translational oncology, making her a key figure in the emerging field of lipid modification-based cancer therapeutics.