Aishwarya Iyer

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About

Dr. Aishwarya Iyer is a leading researcher in chemical biology and cancer therapeutics, with a primary focus on protein lipidation and its role in oncogenic signaling. Her most-cited work, "Targeting N-myristoylation for therapy of B-cell lymphomas" (2020, 64 citations), represents a landmark contribution to the field. In this study, Dr. Iyer systematically investigated N-myristoyltransferase (NMT) as a therapeutic target, demonstrating that cancer cells—particularly B-cell lymphomas—exhibit elevated NMT expression, making them vulnerable to NMT inhibition. Her research elucidated how disrupting N-myristoylation impairs membrane targeting of key signaling proteins, thereby suppressing tumor growth. This work has opened new avenues for developing targeted therapies against hematologic malignancies. Beyond this flagship paper, Dr. Iyer has made significant contributions to understanding post-translational modifications in disease contexts, bridging fundamental biochemistry with translational oncology. Her research has been cited extensively by groups exploring protein acylation inhibitors, and she is recognized for her innovative approaches to targeting previously "undruggable" protein-lipid interactions. Dr. Iyer's work continues to inspire new strategies in precision cancer medicine.