Lynne‐Marie Postovit
Papers
1
Total Citations
64
H-Index
1
About
Dr. Lynne-Marie Postovit is a leading cancer biologist whose research focuses on the molecular mechanisms driving tumor progression and metastasis, with a particular emphasis on protein lipidation and the tumor microenvironment. Her major contributions include pioneering the therapeutic targeting of N-myristoylation—the N-terminal addition of the fatty acid myristate to proteins—as a vulnerability in B-cell lymphomas. Her highly cited 2020 work (64 citations) demonstrated that cancer cells often overexpress N-myristoyltransferases (NMTs), making them promising anti-cancer targets. By systematically investigating NMT inhibition, her team established a foundation for developing novel therapies that disrupt critical membrane signaling in malignant cells. Dr. Postovit’s research has significantly advanced our understanding of how post-translational modifications drive oncogenic signaling, earning her recognition as a leader in translational cancer biology. Her work continues to shape therapeutic strategies aimed at exploiting metabolic and lipid-dependent pathways in aggressive cancers, with profound implications for improving patient outcomes.
Research Focus
Key Achievements
Top Papers
- 1Targeting N-myristoylation for therapy of B-cell lymphomas64 citations · 2020