James C. Lacefield
Papers
6
Total Citations
65
H-Index
5
About
James C. Lacefield is a leading figure in preclinical image-guided interventions, specializing in the development of robotic systems for ultra-precise needle positioning in small animal models. His core research bridges robotics, medical imaging, and biomedical engineering to enable minimally invasive procedures in rodents. Lacefield’s major contribution is the design, calibration, and validation of a novel needle-positioning robot capable of targeting brain structures with sub-100-micrometer error. His most cited work (2007, 26 citations) established the foundational system, while subsequent studies integrated it with volumetric microcomputed tomography and high-frequency ultrasound for stereotactic interventions. Notably, his 2013 paper introduced a remote center of motion to simplify the robotic design while maintaining accuracy. Across his publications, Lacefield has demonstrated robust registration techniques—linking 3D ultrasound and CT images to the robot—enabling reliable targeting of biologically relevant locations. His work has direct implications for drug delivery, tumor modeling, and neuroscience research, offering a transformative tool for translational studies. With a cumulative impact spanning over a decade, Lacefield’s innovations continue to shape the future of automated, image-guided preclinical interventions.
Research Focus
Key Achievements
Top Papers
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