Shawn Stapleton
Papers
3
Total Citations
90
H-Index
3
About
Shawn Stapleton’s research lies at the intersection of cancer biology, drug delivery, and biomedical engineering, with a focus on understanding how the physical tumor microenvironment governs the efficacy of nanotherapeutics. His major contributions center on the intra-tumoral relationship between microcirculation, interstitial fluid pressure (IFP), and the accumulation of liposomal drug carriers. In a highly cited 2015 study (74 citations), Stapleton demonstrated that regions of high IFP and poor perfusion directly correlate with reduced liposome uptake, providing a mechanistic explanation for the heterogeneous distribution of nanomedicines in solid tumors. To enable such spatially precise measurements, he also developed a micro-CT guided robotic needle positioning system for small animal interventions (2013), a novel tool that simplifies remote-center-of-motion design while maintaining high targeting accuracy. His 2016 work further quantified these spatial perfusion-IFP-liposome relationships, offering a framework for predicting therapeutic outcomes. Stapleton’s integrated approach—combining advanced imaging, robotics, and quantitative physiology—has provided critical insights for designing more effective, physically-informed cancer nanotherapies.
Research Focus
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Top Papers
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