Michael Milosevic
Papers
1
Total Citations
74
H-Index
1
About
Michael Milosevic is a leading figure in radiation oncology and cancer biology, whose research has fundamentally reshaped our understanding of how tumor physiology governs treatment response. His key contributions lie at the intersection of tumor microcirculation, interstitial fluid pressure, and drug delivery, with a particular focus on the role of the tumor microenvironment in modulating therapeutic efficacy. Milosevic’s seminal 2015 paper, “The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation,” which has garnered 74 citations, is a cornerstone of his work. In this study, he elucidated the complex interplay between abnormal tumor vasculature and elevated interstitial fluid pressure, demonstrating how these factors create a physical barrier that impedes the uniform accumulation of nanoscale therapeutics, such as liposomal drugs. This work provided a mechanistic framework for understanding why many promising anticancer agents fail in solid tumors, and it has directly informed the design of strategies to normalize the tumor microenvironment to improve drug delivery. Milosevic’s research has had a profound impact on the field, bridging the gap between basic tumor biology and clinical oncology, and his insights continue to guide the development of more effective, physiology-aware cancer treatments.
Research Focus
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Top Papers
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