G.T. Montelione

About

G.T. Montelione is a leading structural biologist whose work has significantly advanced the field of protein production and structural genomics. As a key figure in the Northeast Structural Genomics Consortium, Montelione pioneered high-throughput robotic cloning and protein production platforms, enabling the rapid characterization of thousands of proteins. His landmark 2005 paper on this platform has garnered over 130 citations, underscoring its foundational impact on structural biology. Montelione's research also extends to viral pathogenesis, notably through his 2007 study on the influenza A virus NS1 protein, which revealed conserved surface features forming the double-stranded RNA binding site—a critical insight into how the virus counters host antiviral defenses. This work, with 93 citations, highlights his contributions to understanding virulence mechanisms. Additionally, his 2008 assessment of the NIH-NIGMS Protein Structure Initiative's production centers (65 citations) helped shape large-scale structural biology efforts. Through these achievements, Montelione has not only advanced protein structure determination but also provided essential tools and knowledge for combating infectious diseases, making him a pivotal figure in modern structural genomics.

Research Focus

Key Achievements

Top Papers

1. 1
   Robotic Cloning and Protein Production Platform of the Northeast Structural Genomics Consortium

   130 citations · 2005
2. 2
   Conserved Surface Features Form the Double-stranded RNA Binding Site of Non-structural Protein 1 (NS1) from Influenza A and B Viruses

   93 citations · 2007
3. 3
   Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers

   65 citations · 2008

Key Collaborators

Contact & Links