Liang-Yu Shih
Papers
1
Total Citations
130
H-Index
1
About
Liang-Yu Shih is a structural biologist whose work has significantly advanced high-throughput protein production and structural genomics. As a key contributor to the Northeast Structural Genomics Consortium, Shih co-developed a pioneering robotic cloning and protein production platform that streamlined the process of generating recombinant proteins for structural studies. This foundational work, detailed in a 2005 paper with over 130 citations, enabled the rapid, parallel expression and purification of thousands of proteins, accelerating the determination of three-dimensional structures and deepening our understanding of protein function. Shih’s contributions have been instrumental in establishing automated pipelines that reduce bottlenecks in structural biology, making large-scale genomic projects more feasible. By integrating robotics with molecular biology, Shih helped transform how researchers approach protein characterization, impacting fields from drug discovery to enzymology. Their work remains a cornerstone for laboratories seeking efficient, reproducible methods in structural genomics, and continues to inspire innovations in protein engineering and high-throughput screening.
Research Focus
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Top Papers
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