Chi Kent Ho
Papers
1
Total Citations
130
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1
About
Chi Kent Ho is a pioneering structural biologist whose work has significantly advanced high-throughput protein production and structural genomics. His key research areas include robotic automation for protein expression, structural biology, and the development of scalable platforms for macromolecular crystallography. Ho’s most notable contribution is the design and implementation of a robotic cloning and protein production platform for the Northeast Structural Genomics Consortium, a landmark project that streamlined the generation of thousands of proteins for structural determination. This work, detailed in his highly cited 2005 paper (130 citations), established a paradigm for efficient, reproducible protein production that has been widely adopted by structural genomics initiatives worldwide. By integrating automated cloning, expression testing, and purification, Ho’s platform reduced manual labor and increased throughput, enabling the rapid characterization of protein structures critical for understanding biological function and disease. His contributions have not only accelerated the pace of structural biology but also provided a foundational model for large-scale collaborative research. Chi Kent Ho’s work remains a cornerstone in the field, inspiring new generations of researchers to embrace automation and systems-level approaches in structural genomics.
Research Focus
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